Devil Fruits are the main source of power in the world of One Piece. They were introduced to fans right from the start, with the first Devil Fruit shown being Luffy’s Gomu Gomu no Mi, the Rubber Fruit. As One Piece: The Final Saga continues, the mysteries surrounding these fruits only deepen.
One of the biggest questions is how Devil Fruits were created and which was the very first. Although Oda has never given a clear answer, he has scattered clues throughout the story suggesting that the Hito Hito no Mi, Model: Nika, is the original Devil Fruit.
Hito Hito no Mi, Model: Nika may be the first Devil Fruit ever made

When looking at the origin of Devil Fruits, fans know they were created by humans. Vegapunk has tried to replicate Devil Fruits, recreating the achievements of the Ancient Kingdom. This clearly means that people living 900 years ago were the ones who first made Devil Fruits.
This is also directly supported by King Harley, who declared that the Forest God sent demons to the second world, which implies that Devil Fruits first appeared in the Second World.
To understand which Devil Fruit was created first, we need to consider Vegapunk’s explanation: Devil Fruits are simply a path to another form of human evolution. Every Devil Fruit exists because of the wishes or dreams of someone who lived before. This means Devil Fruits come directly from human desires.
Nika may have been born from the wishes of the oppressed

To identify the first Devil Fruit, we must look at the state of the One Piece world long ago. The world was first destroyed after the First World. In the Second World, new life emerged, and Devil Fruits were born during this era.
Although life returned, oppression and slavery still ran rampant. Nika appeared when oppression reached its peak, and the collective human desire was freedom from chains.
For this reason, the first Devil Fruit born from humanity’s collective wish is the Hito Hito no Mi, Model: Nika. This fruit was eaten by Joy Boy, who came from the Ancient Kingdom and later led the fight against the 20 kings.
Nika’s imagination may have inspired other Devil Fruits

In One Piece, Nika appears whenever oppression peaks and the people call for him. Regarding other Devil Fruits, they too were created from human imagination and desires.
However, Nika himself may have played a key role in bringing them into existence. According to Oda, Nika’s power is the power of imagination. With such rich creativity, he can create anything. Perhaps it is this ability that allowed Nika to imagine different Devil Fruits for different people around the world.