The devil fruit power system is one of Eiichiro Oda’s greatest creations in One Piece. Conceptually, it’s simple: eat the fruit and gain abilities. But the difference between an average user and a legend lies in mastery. Here are devil fruits that seem straightforward but demand intense strategy and relentless training to unlock their full potential.
1. Hito Hito no Mi, Model: Nika – Mythical Zoan

Luffy’s signature devil fruit is the strongest we’ve seen, with the power to bend reality itself. But the cost is huge. When awakened and reaching the Nika state (Gear 5), it drains his stamina wildly.
If Luffy pushes too long without recharging, his life force and energy are completely drained. What we saw in Wano and Egghead Island clearly shows this fruit can carry the world but can also cause the user to collapse mid-battle.
2. Yami Yami no Mi – Logia

Normally, Logia users become intangible by transforming into elements. But the Yami Yami no Mi is an exception. While it can nullify other devil fruit powers through a black hole’s gravitational pull, it doesn’t let Blackbeard become invisible or dodge attacks.
Instead, because of its absorbing nature, Blackbeard takes double damage from hits. Mastering it requires recklessness and incredible control over one’s wounded ego to avoid falling before defeating opponents.
3. Ope Ope no Mi – Paramecia

Many consider this the most overpowered devil fruit, but in the hands of someone clueless about medicine, it’s just a cheap toy. To fully utilize the “Room” ability, the user must have real surgical knowledge to operate, transplant, and precisely position an opponent’s body.
Law is not just a fighter, he’s a genius doctor. His combination of combat skill and deep medical expertise turns the Ope Ope no Mi into a weapon even the Four Emperors fear.
4. Ito Ito no Mi – Paramecia

On the surface, the Ito Ito no Mi just creates sharp threads. But Doflamingo’s use elevated it to a symbol of manipulation. Turning threads into tools to control people’s actions or even “hang” bodies on clouds to move requires sharp instincts and high-level strategy.
Doflamingo doesn’t use threads to slash, he turns entire kingdoms into chessboards, controlling every piece with his hands.
5. Hana Hana no Mi – Paramecia

The ability to sprout body parts anywhere sounds simple, but only Nico Robin has made it one of the strongest combat powers. Instead of just growing hands to bind enemies, Robin creates giant replicas strong enough to take down elite fighters like Black Maria of the Tobi Roppo. The need to observe, focus, and visualize complex structures to turn her body into a weapon shows Robin’s mastery is truly exceptional.