The Hito Hito no Mi is one of the most unique Devil Fruits in One Piece. Beyond its standard form that grants animals human intelligence, this fruit has several Mythical variants with godlike powers, such as Nika and Daibutsu.
So far, only a few characters have been confirmed to use variants of the Hito Hito no Mi, and most of them rank among the world’s strongest. Here is the ranking of the top 5 strongest Hito Hito no Mi users in One Piece.
5. Onimaru (Hito Hito no Mi, Model: Onyudo)

Onimaru is a special case, similar to Tony Tony Chopper, as an animal who ate the Hito Hito no Mi. However, his Devil Fruit is the Mythical variant Model: Onyudo.
Thanks to this power, the Komagitsune fox can transform into a powerful warrior monk. During the Wano arc, Onimaru fought evenly against Roronoa Zoro when the Straw Hat swordsman wielded two swords.
Despite this, Onimaru’s combat record is limited. Once Zoro understood his fighting style, he quickly defeated Onimaru in their next encounter. For this reason, Onimaru deserves a spot on the list but lacks the strength to compete with higher-ranked users.
4. Tony Tony Chopper (Hito Hito no Mi)

Chopper uses the standard version of the Hito Hito no Mi and is one of the rare reindeer to gain human intelligence through a Devil Fruit.
With the help of the Rumble Ball, the Straw Hats’ doctor can shift between multiple forms, giving him great versatility in battle.
However, Chopper still struggles against high-level opponents like Queen of the Beasts Pirates.
Notably, in the Final Saga, Chopper revealed a new ability to heal those affected by Domi Reversi with a single punch. This suggests that the Hito Hito no Mi may not only grant combat power but also the ability to restore humanity to others.
3. Sengoku (Hito Hito no Mi, Model: Daibutsu)

Former Marine Admiral Sengoku is one of the few users of the Mythical Hito Hito no Mi, specifically Model: Daibutsu. When transformed into a giant Buddha statue, Sengoku can unleash powerful shockwaves capable of knocking back multiple enemies at once.
Beyond his immense strength, Sengoku is known as a Marine strategic genius. Even Pirate King Gol D. Roger admitted that only Garp and Sengoku were worthy opponents in the Marines.
However, Sengoku has never been shown fighting at full power on screen, leaving his true strength somewhat of a mystery.
2. Monkey D. Luffy (Hito Hito no Mi, Model: Nika)

After awakening his Devil Fruit, Luffy was confirmed as the current user of the Hito Hito no Mi, Model: Nika.
Gear 5 grants the Straw Hat captain the ability to manipulate his body shape, change size, turn his surroundings into rubber, and create surreal cartoon-like effects. Combined with mastery of all three advanced Haki types, Luffy is now one of the strongest characters in the One Piece world.
His achievements include defeating Kaido, one of the Four Emperors, overcoming CP0’s Rob Lucci, overpowering Admiral Kizaru, and defeating the Holy Knight Shepherd Sommers.
Still, Luffy faces challenges against the Five Elders, showing that despite reaching top-tier status, he has room to grow.
1. Joy Boy (Hito Hito no Mi, Model: Nika)

Topping the list is none other than Joy Boy, the original wielder of the Hito Hito no Mi, Model: Nika during the Void Century.
What sets Joy Boy far ahead of the current Luffy is his nearly unimaginable Haki mastery.
The clearest proof is his ability to store Conqueror’s Haki within the body of Emet for hundreds of years, with that power still fully intact today. This is an achievement Luffy has yet to reach.
Moreover, Joy Boy is the most feared figure in World Government history. While Luffy still struggles against the Five Elders, Joy Boy’s Conqueror’s Haki alone was enough to shatter their powers and force most of them back to Mary Geoise.